Manchester Metropolitan University

Faculty Member, School of Biology, Chemistry & Health Science

Senior Lecturer

About

Claudius D'Silva., Ph.D. FRSC.  Senior Lecturer In Chemistry, Born in India, educated in the UK  at the University  of  Lancaster ( Chemistry) and  University of Birmingham (Chemistry).  He held Fellowships at the  University  of Essex, University  of Leeds and the  University of Michigan , Ann Arbor, USA. He held  the GEC/Fellowship of Engineering  Senior Fellowship in Molecular & Biomolecular Electronic  at Univ of Wales, Bangor, UK and then  was appointed Senior Lecturer at the  Univ of Sunderland.  He moved to Manchester Metropolitan Univ in 1993.


Principal Collaborators:

Professor Stephen Barker (Head of Carbohydrate Chemistry) &  Dr Charles Gray (Peptide Chemistry), Univ of Birmingham.UK

Dr Kenneth. Douglas ,  Univ of Essex. UK (currently  (Professor, Head of Pharmacy, Univ of Manchester)

Professor Vincent Massey.FRS & Professor Charles Williams, Bioloigical Chemistry, Medical School, Univ of Michigan, Ann Arbor, Michigan.

Professor Ron Pethig, Professor T.J.Lewis, Professor Martin Taylor, Dr John Jones, Dr Chris Barnes, Dr Hwyel Morgan.(currently  Professor, School of Microelectronics, Univ of Southampton), Institute of Molecular & Bioelectronics, Univ of Wales, Bangor.




Current Research

The synthesis  of nucleotide analogues based on Uracil  & Adenine as antimicrobial, anticancer, antiparasitic  and antiviral agents.

The use of azides and alkenes in click reactions to prepare organotransistion metal photosensitisers.

The use of reactive intermediates (azides, carbenes, radicals) and silanes to enhance adhesion, functionalisation  and encapsulation of surfaces.


The synthesis of chemical compounds (peptides, reactive agents) as antiparasitic, anticancer agents  targeting the glutathione and trypanothine cycle (oxidative stress) & cell membranes.

The synthesis of  electrophillic nitrogen compounds as active site directed reagents targeting enzymes associated with oxidative stress for use as anticancer and antiparasitic reagents.

The synthesis of heterocyclic pyrrole derivatives and their use in the preparation of polypyrrole film for use in sensors, and biomedical applications.

Patents

Surface Functionalised adhesion. Patent GB 03221736, DCTA ..

S-Blocked Glutathiones. UK patent filed, UK Patent GB2332676 granted.

Ethynylbenzene Polymers. UNITED KINGDOM PATENT Application No. 9700897.3  17 Jan 1997.

Fluorescent Polymers. UNITED KINGDOM PATENT Application No. 9700830.4  16 Jan 1997.

Catenane Polymers. UNITED KINGDOM PATENT Application No. 9700114.3 6 Jan 1997.

Contact Information